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Human leukocyte antigen (HLA)
typing is used to match patients
and donors for bone marrow or
cord blood transplants (also
called BMT). HLA are proteins —
or markers — found on most cells
in your body. Your immune system
uses these markers to recognize
which cells belong in your body
and which do not.
A close match between your HLA
markers and your donor's can
reduce the risk that your immune
cells to attack the donor's
cells or that the donor's immune
cells to attack your body after
the transplant. If you need an
allogeneic transplant (which
uses cells from a family member,
unrelated donor or cord blood
unit), your doctor will take a
blood sample to test for your
HLA type.
HLA matching basics
A well-matched donor is
important to the success of your
transplant. You inherit half of
your HLA markers from your
mother and half from your
father, so each brother and
sister who has the same parents
as you has a 25% chance of
matching you. It is unlikely
that extended family members
will match you. However, your
parents and/or children may also
be tested to confirm your HLA
typing and to make sure no
possible donors are overlooked.
About 70% of patients who need a
transplant do not have a
suitable donor in their family.
A close HLA match improves the
chances for a successful
transplant. Close matching:
Promotes engraftment-
Engraftment is when the donated
cells start to grow and make new
blood cells.
Reduces the risk of a
post-transplant complication
called graft-versus-host disease
(GVHD). - GVHD occurs when the
immune cells from the donated
marrow or cord blood (the graft)
attack your body (the host).
PGD/PCR - HLA typing
It is now possible to undergo
PGD for human leukocyte antigen
(HLA) matching to you for the
purpose of having a HLA-matched
hematopoietic progenitor cell (HPC)
donor for the Thalassemia
affected child. The PGD
procedure allows genetic testing
to be performed on early embryos
before implantation and
pregnancy development for the
purpose of selecting only those
embryos that are HLA matched to
the affected child.
When a couple has a child with a
single gene disorder like
Thalassemia that requires an HPC
transplant, the optimal source
of cells needed for transplant
is an HLA-matched sibling.
Donors cells need to be HLA-matched
to an affected child avoid any
chance for the transplanted
cells to react against the
child’s body. If you undertake a
natural pregnancy in the hope of
having a child who is an HLA
match to your affected child,
there is 1 in 5 chance of
conceiving a child who is an HLA
match to the affected biological
child.
Following IVF, PGD can be used
for selecting and transferring
only the embryos that are HLA
matched to your affected child.
Each embryo has a 1 in 5 chance
of matching the affected
biological child. With PGD, the
goal is to select those embryos
that are HLA-matched and
transfer them. In this process,
we can significantly increase
the chance to have a child that
is HLA-matched to your affected
child.
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REQUEST
A FREE CONSULTATION |
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QUESTIONS OR COMMENTS ON BANGKOK
FERTILITY ?
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CALL |
+66(0)83 535 1619, Fax: +66(0)2 9240734 |
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WRITE |
77/4
The Emerald Garden village, Leab Klong-Ann Rd.,
Bangplub, Pakgred, Noothaburi, 11120, Thailand
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E-MAIL |
consult@bangkokfertility.com |
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Prime Health Co., Ltd. 2007 - 2010. All Rights Reserved. |
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